Probiotics for Gut Health

“The composition of our gut microbiota and its activity as a microbial community is closely related to our health and well-being.”

What are probiotics for gut health?

Probiotics for gut health are live microorganisms, such as bacteria and yeasts, found naturally in the human gastrointestinal tract. These beneficial bacteria form what is known as the intestinal microbiota or gut flora and must always be in balance to maintain good digestive health.

Probiotics can be found in some foods, such as yogurt, kefir and sauerkraut, and are also available in supplement form. When consumed, probiotics can colonize the gut and improve the composition of the gut microbiota, which can provide a number of health benefits, such as improved digestion, strengthening the immune system, reducing inflammation and preventing antibiotic-associated diarrhea, among others.

It is important to note that the benefits of probiotics vary according to the species and strain of microorganism. Just as there are intestinal probiotics, there are also vaginal probiotics with their own strains that normally live in the woman’s vagina.

How do probiotics act on the intestinal microbiota?

Probiotics for gut health act on the intestinal flora in several ways. First, they can colonize the gut and compete with pathogenic bacteria and other harmful microorganisms, which helps maintain a healthy balance of intestinal microbiota. They can also produce organic acids and other substances that inhibit the growth of pathogenic bacteria and promote the growth of beneficial bacteria.

In addition, probiotics can stimulate the immune system, both locally in the gut and throughout the body, helping to support immune health and thus helping to prevent infection and disease.

Probiotics can also improve food digestion and nutrient absorption, which can improve overall health.

Probiotics also have the ability to modulate the inflammatory response. Some strains of probiotics for gut health reduce intestinal inflammation, which may be beneficial in treating disorders such as inflammatory bowel disease.

person taking probiotics for gut health

How do they differ from prebiotics?

As explained above, probiotics are live microorganisms, while prebiotics are non-digestible compounds found in some foods, such as dietary fiber, that stimulate the growth and activity of beneficial bacteria in the gut.

In short, a prebiotic is the food of the probiotic.

In summary, probiotics are microorganisms that colonize the intestine and prebiotics are compounds that are not digestible by humans but are digestible by the good microorganisms in the intestine, causing them to proliferate and giving rise to their beneficial effects on digestive and general health.

What are gut health probiotics used for?

Probiotics for gut health have several advantages and potential fields of application in human health. Some of the most prominent benefits from taking them are:

  • Improve gut health: probiotics can improve gut health by promoting the growth of beneficial bacteria, reducing inflammation and improving the intestinal barrier. They help restore intestinal flora.
  • Strengthens the immune system: Probiotics can help strengthen the immune system, both in the gut and throughout the body, which can help prevent infection and disease.
  • Improves digestion: Probiotics can improve digestion and nutrient absorption, which can help improve overall health.
  • Treating gastrointestinal disorders: Probiotics have been used to treat a variety of gastrointestinal disorders, such as irritable bowel syndrome, inflammatory bowel disease, and both infectious and antibiotic-associated diarrhea.
  • Reducing lactose intolerance: Some probiotic strains may help reduce lactose intolerance by breaking down lactose in the gut.

Are gut probiotics safe?

In general, probiotics for gut health are safe for most people and offer a number of health benefits.

In some cases some people may experience mild gastrointestinal side effects, such as gas, bloating or diarrhea that disappear within a few days.

People with weakened immune systems should avoid taking probiotics as well as seriously ill people who should first consult with their specialist.

Top 40 Best Probiotics for Gut Health

These are our top picks for gut health:

Align Probiotic Gummies

1 billion probiotics


1 Strain

Align Probiotic DualBiotic is a pleasant-tasting gummy containing 1 billion colony forming units (cfu) of LactoSpore®, a registered trademark containing a single probiotic species: Bacillus coagulans.

It is a product with several thousand evaluations, all very positive, made by its consumers

The microorganism it contains, Bacillus coagulans, is common in the microbiota of the human gastrointestinal tract and plays a crucial role in maintaining the stability and diversity of the microbiota.

Unlike other acidolactic bacteria, Bacillus coagulans is the only one with the property of producing spores during its life cycle, which gives it a special resistance when crossing the gastrointestinal tract, thus reaching the final part of the large intestine practically intact.

Bacillus coagulans creates an environment that improves the absorption of nutrients, reduces digestive problems and helps fight against allergic situations. It has the capacity to produce short chain fatty acids (butyrate, acetate) which are very important for their energy contribution to the intestinal cells and for creating an acid environment that hinders the growth of pathogenic species.

Clinically validated, it has proven to be a safe and effective bacterium in the treatment of diarrhea in individuals with Irritable Bowel Syndrome (1)(2).

It contains Inulin, obtained from Chicory Root, a Prebiotics fiber that reaches the large intestine and promotes the growth of the native or indigenous microbiota.

It has also been shown that the administration of Bacillus coagulans together with inulin-derived prebiotics reduces abdominal pain and improves constipation in cases of Irritable Bowel Syndrome (3).

Manufactured by Align Probiotic, a brand of the American group Procter & Gamble, which provides an extra guarantee to this product.

It has several thousand very positive ratings from its consumers.


  • Trusted brand
  • High resistance to gastrointestinal tract.
  • Goomies. Easy to take


  • Only one strain
  • Contains sugar
Align DualBiotic, Prebiotic + Probiotic for Women and Men, Help Nourish and Add Good Bacteria for Digestive Support, Natural Fruit Flavors, 60 Gummies
Price: $21.99 ($0.37 / Count)
You save: $3.00 (12%)

Align Probiotic Digestive Support

1 billion probiotics

Chewable tablets

1 Strain

Align Probiotic Digestive Support is a probiotic supplement with a single strain in its formula.

It contains 1 billion cfu/tablet of Bifidobacterium longum 35624. This particular strain is indicated for the treatment of Irritable Bowel Syndrome (IBS), as confirmed by several studies and clinical trials conducted with this strain (4)(5).

They are chewable tablets, which makes it easier to take them without the need to administer them with a drink.

It has a pleasant banana and strawberry flavor and does not have soy or gluten derivatives, which makes it suitable for people with celiac disease.

Manufactured by Align Probiotic, a brand belonging to the US multinational Procter & Gamble and with clinical applications recommended by the Clinical Guide of the Alliance for Education on Probiotics (AEProbio) in both the USA and Canada.


  • Trusted brand
  • Also for children


  • Formula with only one microorganism
Align Probiotic, Chewable Probiotic Tablets for Women and Men, Fortify Your Digestive System 24/7 with Healthy Bacteria, #1 Recommended Probiotic by Doctors and Gastroenterologists, 24 Tablets
Price: $28.49 ($1.19 / Count)
You save: $2.85 (9%)

Culturelle Probiotic

10 billion probiotics


1 Strain

Culturelle Probiotic contains one of the most studied and known probiotic species: Lactobacillus rhamnosus GG, with almost 1000 studies and over 200 clinical trials conducted with it. It is a very robust bacterium with great resistance to passage through the gastrointestinal tract. It’s among the best probiotics for digestive health.

Each Culturelle Probiotic capsule provides 10 billion cfu of Lactobacillus rhamnosus GG. This product also contains Inulin, a Prebiotics fiber extracted from Chicory Root.

This strain has multiple therapeutic indications, including the prevention of antibiotic-associated diarrhea (7). It also improves intestinal discomfort such as gas and bloating.

On the other hand, this probiotic is also a good option for the reduction of the side effects produced by the treatment for the eradication of Helicobacter Pylori (8)

Highly recommended product, with many and very positive evaluations by its consumers.

Manufactured by the DSM group, a Dutch company with more than 100 years of history and whose last 20 years have been dedicated to nutrition and health solutions.


  • Extensively studied strain
  • Trusted Brand
  • With Chicory Root Inulin


  • Formula with only 1 strain
Culturelle Daily Probiotic Capsules For Men and Women, Most Clinically Studied Probiotic Strain, Proven to Support Digestive and Immune Health, 30 Count
Price: $15.99 ($0.53 / Count)
You save: $0.81 (5%)

Just Thrive probiotic

500 millon probiotics


1 Strain

Digestive Advantage Probiotic Supplement from the American company Schiff. It contains 500 million cfu of Bacillus coagulans GBI-30.

This strain of Bacillus coagulans GBI-30 has shown therapeutic efficacy in diarrhea associated with irritable bowel disorder, according to a trial conducted with 52 people with this type of pathology and which showed how patients who took the probiotic improved their symptoms compared to those who took a placebo (9)

Another similar study showed a reduction in gastrointestinal discomfort (abdominal pain, flatulence) after meals in patients taking this probiotic compared to those taking a placebo (10)

In addition, Just Thrive probiotic contains lactase, an enzyme that helps hydrolyze the lactose present in most dairy foods and which causes numerous discomforts to all those who are lactose intolerant.


  • Easy to take gummies
  • Well documented strain


  • Not very potent formula
  • Formula with only one strain
Digestive Advantage Probiotic Gummies For Digestive Health, Daily Probiotics For Women & Men, Support For Occasional Bloating, Minor Abdominal Discomfort & Gut Health, 80ct Natural Fruit Flavors
Price: $12.98 ($0.16 / Count)
You save: $6.71 (31%)

Just Thrive probiotic & antioxidant

3 billion probiotics


4 Strains

Probiotic supplement with 4 strains of bacteria of the same genus Bacillus.

It has a total of 3 billion of microorganisms of the following strains 

  • Bacillus indicus HU36
  • Bacillus coagulans SC-208
  • Bacillus clausii SC-109
  • Bacillus subtilis HU58

These are strains that have the ability to sporulate, which gives them greater resistance to other probiotics of other genera.

Among the diverse therapeutic activities that we can find in these strains, we can highlight the antioxidant activity thanks to the carotenoids that Bacillus indicus HU36 produces (11) as well as its activity against pathogenic microorganisms thanks to the production of antimicrobial substances that Bacillus subtilis HU58 carries out (12).

On the other hand, Bacillus coagulans SC-208 (1)(2) has shown therapeutic activity against diarrhea caused by Irritable Bowel Syndrome and there is also an aid to the modulation of the immune system thanks to Bacillus clausii SC-109 (13).


  • Product also suitable for children
  • Patented strains and with supporting studies


  • Somewhat expensive

Garden of Life Primal Defense

5 Billon probiotics


13 Strains

Primal Defense is Garden of Life’s line of probiotics for gut health based on a blend of microorganisms called Homeostatic® Soil Organisms (HSOs). These are microorganisms that would be naturally present in food if they had not been treated with pesticides, herbicides or other chemicals, and it is precisely these microorganisms that Garden of Life Primal Defense provides.

Each Garden of Life Primal Defense capsule contains 5 billion of 13 probiotics from the genera LactobacillusBifidobacterium and Bacillus as well as a common yeast in these products, Saccharomyces boulardii.

The recommended dose is 3 capsules per day, which is a daily dose of 15 billion cfu.

Garden of Life Primal Defense helps maintain a balanced intestinal microbiota and a strong, healthy immune system. It thus helps to regulate the intestinal movement and improves the immune system while making us have a better digestion and without discomfort.

It is a product of excellent quality and very well valued by consumers, which will provide an adequate balance of beneficial bacteria against pathogenic microorganisms while creating a healthy intestinal environment.


  • Wide range of probiotics in formula
  • Well known brand name


  • Does not indicate strains with references to studies
Garden of Life Primal Defense Ultra Ultimate Probiotic Formula - 15 Billion CFU and 13 Strains of Probiotics Plus HSOs for Healthy Digestive Balance, Vegetarian and Gluten Free, 90 Capsules
Price: $39.45 ($0.44 / Count)
You save: $9.93 (18%)

Garden of Life 50 and wiser 

85 billon probiotics


32 Strains

Two specific Garden of Life Raw Probiotics products designed for men and women over 50 with probiotics for gut health, vitamins and digestive enzymes.

Both Garden of Life Raw Probiotics products have a practically similar composition with 85 billion microorganisms from 32 species of beneficial bacteria, among which are 10 species of the genera Lactobacillus and Bifidobacterium and 22 probiotic species derived from kefir that also has this product since in its composition there is also a kefir culture concentrate that is a natural probiotic obtained from fermented milk and with some resemblance to yogurt.

The only difference that exists between them is the amount of some of the minerals that there are in the product since this one varies according to the product for men or for women.

In addition, in the case of the Garden of Life Raw Probiotics for men over 50, the presence of Lactobacillus fermentum stands out, with beneficial properties for maintaining cholesterol within the correct range (14).

In the case of Garden of Life Raw Probiotics for women over 50, the presence of Lactobacillus reuteri and Lactobacillus rhamnosus, two very important probiotic species for women’s vaginal health, stands out. The microbiota is mainly formed by bacteria of the genus Lactobacillus and tends to decrease with age.

In addition to more than 30 probiotics, Garden of Life Raw Probiotics also has 9 vitamins (vitamin C, D, E and several B group vitamins) with a contribution close to 100% of the daily needs depending on whether you are a man or a woman.

Garden of Life Raw Probiotics also provides essential minerals, Calcium, Iodine, Magnesium, Selenium, Copper, Manganese, Chromium and Molybdenum that are involved in essential processes in our body and that we do not always acquire with our diet.

Finally, to facilitate digestion, the product also has several digestive enzymes such as lactase, which degrades the lactose in milk, or proteases, for the digestion of proteins.

In short, Garden of Life Raw Probiotics is a very complete product because of its great amount of probiotic, vitamins, minerals and digestive enzymes. It has numerous positive evaluations by its consumers and also has the guarantee of Garden Of Life, one of the main manufacturers of probiotic products in the United States.


  • Powerful formula
  • Best probiotic for women over 50
  • Wide range of microorganisms


  • No indication of the strains it contains

Garden of Life Raw Probiotics Ultimate Care

100 billon probiotics


34 Strains

Garden of Life RAW Probiotics Ultimate Care has no less than 100 billion of a total of 34 beneficial bacteria, many of them derived from kefir, making it one of the most powerful probiotics on the market.

These microorganisms included in this product help digestionpromote regularitysupport the immune system and help to have an intestinal microbiota balanced with a healthy bacterial population since what this product does is to replace all those bacteria that for various reasons, treatments, medication, age, etc. have been decreasing.

Garden of Life RAW Microbiome Ultimate Care also contains digestive enzymes – proteases – that help digest proteins as well as fruits such as Red Bell Pepper that provide vitamins (including vitamin A, vitamin C or vitamin K) and antioxidants.

Finally, it also contains Green Pea, Carrot, Plum, Cherry, Strawberry and Raspberry which also provide mineralsvitamins and antioxidants.

It is therefore a very complete product, with a large amount of probiotics for gut health from more than 30 different species in addition to the contribution of vitamins, antioxidants and minerals. Garden of Life ensures that in its Raw Probiotics line all its components are kept at low temperature throughout the manufacturing process, storage and transport, so that all its components are kept intact as they have not been degraded by the effect of heat.


  • Powerful formula
  • Wide range of microorganisms


  • No indication of the strains it contains
Garden of Life Raw Probiotics for Women and Men Ultimate Care 100 Billion CFU Shelf Stable Non Refrigerated Probiotic Supplement for Adults, Clinically Studied Strains, Digestive Enzymes, 30 Capsules
Price: $33.90 ($1.13 / Count)
You save: $4.59 (12%)

Garden of Life Ultra Probiotic

90 billon probiotics


15 Strains

In this case, it is a very potent probiotic supplement from Garden of Life as it contains 90 billion of 15 probiotics for gut health. It’s probably the best probiotic with lactobacillus acidophilus. It’s probably the best probiotic with bifidobacterium lactis hn019.

In this way, the health of the microbiota or intestinal flora and especially the large intestine, specifically the colon, is enhanced. The presence of the Lactobacillus acidophilus NCFM ® strain stands out, a bacterium which, in combination with Bifidobacterium infantis, has shown an improvement in the symptoms (abdominal pain, swelling, diarrhea, etc.) in patients with Irritable Bowel Syndrome, according to a study carried out with 26 patients with this pathology (6)

Like other probiotics from Garden of Life Dr. Formulated, it contains Potato Resistant Starch and Acacia Fiber, two prebiotics that promote the development of indigenous microbiota in the gut.


  • Powerful formula
  • Wide range of microorganisms
  • Contains Lactobacillus acidophilus NCFM, a well-studied strain


  • No indication of strains except Lactobacillus acidophilus NCFM

Garden of Life Probiotics Urinary Tract

50 billon probiotics


16 Strains

Probiotic supplement specially designed for the prevention of urinary tract infections, especially in women, as this is one of the most common infections of the female gender.

This probiotic is formulated with a compound called Pacran®, a registered trademark of Decas Botanical Synergies, with Cranberry powder that has been shown to be effective to support urinary tract health, since it contains proanthocyanidins, the active component responsible for this antiseptic activity (15).

It has 50 billion of 16 probiotic species, among them Lactobacillus acidophilus NCFM® and Lactobacillus reuteri, being the latter a very important microorganism due to its presence in the vaginal microbiota.

Probiotic very suitable for women since in addition to its antiseptic activity of the urinary tract, it also contains vitamin D3, very important for the absorption of calcium and therefore also important in the prevention of osteoporosis.

As with other probiotic products from Garden of Life Dr. Formulated probiotics, it also contains prebiotics, specifically potato Resistant Starch and Acacia fiber. Prebiotics fiber promote the growth of native microbiota in the intestine.


  • Highly recommended for women
  • Antiseptic activity of urinary tract
  • Contains Lactobacillus acidophilus NCFM®


  • No indication of strains except Lactobacillus acidophilus NCFM

Garden of Life Dr Formulated Probiotics Prostate

50 Billon probiotics


15 Strains

Another Garden of Life probiotics specially designed for men over 45 for its ability to prevent urinary tract disorders and especially those related to benign prostate hyperplasia.

This therapeutic effect is due to the presence of a compound called Fowens® formulated from Cranberry and responsible for this activity, as demonstrated in a clinical study conducted on 124 volunteers with high PSA values (16).

This Garden of Life product also has 50 billion of 15 different probiotic species. Its formula also includes vitamin D3, very important, among other functions, in the absorption of calcium.

Finally, it also has prebiotics fiber, specifically Resistant Starch and Acacia Fiber.


  • Recommended for men with prostate problems
  • Probiotic contribution at intestinal level


  • Does not indicate the strains it contains

Garden of Life Mood Probiotics

50 billon probiotics


16 Strains

Garden of Life Probiotic Supplement with 50 billion of 16 microbial species

In addition to its properties for the rebalancing and balance of the intestinal microbiota, what stands out in this product is the presence of the strains Lactobacillus helveticus R0052 and Bifidobacterium longum R0175.

In a study conducted on 25 volunteers, it was shown that the oral administration of these bacterial strains has beneficial effects for the treatment of psychological problems related to stress which makes it especially indicated in those patients who have a certain tendency to anxiety and depression situations related to stress (17).

On the other hand, it also contains Ashwagandha root. This compound is not a probiotic. It is a herb to which numerous medicinal properties are attributed. One of the best knowns is its ability to reduce stress (18).

It also contains various derivatives of the Blueberry (Vaccinium uliginosum) with antioxidant properties.


  • Very complete
  • With components to manage stress
  • With Ashwagandha root


  • Except for two strains, the rest of the bacteria strains are not indicated.
Garden of Life Dr. Formulated Probiotics Mood+ Acidophilus Probiotic Supplement - Promotes Emotional Well-Being, Relaxation and Digestive Balance - Ashwagandha for Stress Management, 60 Veggie Caps
Price: $28.95 ($0.48 / Count)
You save: $14.15 (30%)

Garden of Life Probiotics Digestive and Immune care 

90 Billon probiotics


11 Strains

Garden of Life Probiotics with 90 billion of 11 different probiotic species

In Garden of Life Probiotics Immune + the presence in the formula of the Lactobacillus acidophilus NCFM®, Lactobacillus rhamnosus GG and Bifidobacterium lactis HN019 strains stands out, all of them very well studied and with very specific therapeutic applications.

Lactobacillus rhamnosus GG is perhaps the most studied bacteria and on which more clinical trials have been conducted. It is a bacterium that has been well studied in relation to its activity on the immune system (19).

Lactobacillus acidophilus NCFM®, very studied in the treatment of the symptoms of the irritable bowel syndrome (1)(2) and Bifidobacterium lactis HN019 that improves the transit time through the gut, reduces symptoms of intestinal disorders (constipation, diarrhea, bloating and abdominal pain) (20) and stimulates the cellular response of the immune system (21).


  • Powerful formula
  • Wide variety of probiotics


  • Only states 3 strains. Of the remaining probiotics it does not identify which strains they are.
Garden of Life Dr. Formulated Probiotics Platinum Series Immune+ 90 Billion CFU Guaranteed, One a Day Probiotic Supplement Acidophilus & Rhamnosus, Vegan, Non-GMO Immune System Support, 30 Capsules
Price: $43.99 ($1.47 / Count)
You save: $7.52 (14%)

Renew Life Probiotic

15-50 Billon probiotics


12 Strains

A product of Renew Life probiotic, a company with more than 25 years in the probiotic supplements sector and which has in its portfolio a series of probiotic supplements of identical formula but different presentations of 15, 30 and 50 billion cfu of beneficial microorganisms.

Renew Life probiotic contains the strains Lactobacillus acidophilus La-14, Lactobacillus plantarum Lp-115, Lactobacillus paracasei Lpc-37 which together with Bifidobacterium lactis Bl-04 have been shown to improve digestive health, with a lower incidence of diarrhea.

Similarly, this group of bacteria provides a rebalancing of the microbiota or intestinal flora with a capacity to modulate the immune system and reduce the incidence of bacterial vaginosis in women (22).

It also includes Bifidobacterium lactis HN019 that improves gastrointestinal transit in patients with constipation problems (20).

The formula also contains Bifidobacterium lactis Bi-07 and Lactobacillus acidophilus NCFM® a combination that supports the immune system. In a study of 465 people, this combination of probiotics was shown to have an effect on the incidence of colds, so people taking these two bacteria had a lower incidence than those taking a placebo. There was also a lower incidence of upper respiratory tract infections (23).

Also, noteworthy is the presence of Lactobacillus rhamnosus GG, a much studied strain and, as we have already mentioned when discussing Culturelle probiotics, it is a very robust probiotic with therapeutic capacity in the treatment of diarrhea associated with antibiotics, as well as for treating the side effects produced during the treatment of eradication of Helicobacter pylori (7).

Very complete probiotic supplement, with registered and patented strains and with several applications to improve health.


  • Patented and registered strains
  • Formulations with various potencies
  • Backed with numerous clinical studies


  • I have not seen any
Renew Life Adult Probiotics, 15 Billion CFU Guaranteed, Everyday Probiotic Supplement for Digestive & Immune Health, Shelf Stable, Gluten Dairy & Soy Free, 60 Capsules
Price: $18.70 ($0.31 / Count)
You save: $4.88 (13%)
Renew Life Adult Probiotics, 30 Billion CFU Guaranteed, Probiotic Supplement for Digestive & Immune Health, Shelf Stable, Gluten Free, Extra Care, For Men & Women, 30 Capsules
Price: $10.99 ($0.37 / Count)
You save: $10.70 (40%)
Renew Life Adult Probiotics, 50 Billion CFU Guaranteed, Probiotic Supplement for Digestive & Immune Health, Shelf Stable, Gluten Dairy & Soy Free, 60 Capsules
Price: $32.40 ($0.54 / Count)
You save: $35.59 (52%)

Nature’s Way Fortify Probiotic

50 Billon probiotics


7 Strains

Fortify Optima has 50 billion of microorganism and is therefore one of the probiotics for gut health on the market with the largest number of beneficial bacteria.

Formula specially designed for men and women over 50 to restore the microbiota that is lost as we age. The strains contained in the formula are:

  • Bifidobacterium lactis (Bl-04®)
  • Bifidobacterium infantis (Bi-26)
  • Bifidobacterium lactis (Bl-07®)
  • Bifidobacterium lactis/bifidum (Bb-02)
  • Lactobacillus acidophilus (La-14)
  • Lactobacillus acidophilus (NCFM®)
  • Lactobacillus gasseri (Lg-36)

Bifidobacterium lactis Bl-04® stands out for its therapeutic efficacy in allergic processes such as hay fever, and Bifidobacterium lactis Bl-07® has the ability to modulate the immune system and combat digestive discomfort by stabilizing the intestinal microbiota, and more obviously, discomfort that is due to treatment with antibiotics.

On the other hand, Lactobacillus acidophilus NCFM® together with Bifidobacterium infantis has shown its efficacy in the treatment of the symptoms of irritable bowel syndrome (6) and Lactobacillus acidophilus La-14, a well studied strain, is very resistant to gastrointestinal conditions (acid and bile) and with great capacity of adhesion to epithelial cells that prevent the proliferation of pathogenic species.

The seven probiotic strains come from the American company Danisco (Dupont), which always offers probiotics for gut health of proven quality and with numerous clinical trials that support their efficacy.

Another probiotic from the American company Nature’s Way.


  • Proprietary strains
  • Well known company


  • Little variety of strains in formula
Nature's Way Fortify Optima Optima Adult 50+ Daily Probiotic, 50 Billion Live Cultures, 7 Strains, 30 Capsules
Price: $25.37 ($0.85 / Count)
You save: $16.62 (40%)

Visbiome Probiotics

112.5 Billon probiotics


8 Strains

Visbiome Probiotics contains the original VSL#3 formula, which was designed by Dr. Claudio De Simone, and which until 2016, was marketed under the trade name VSL#3. Since then, the VSL#3 trade name product does not contain Dr. Simione’s original formula but another very similar one, but without the clinical studies that support the original formula.

The Visbiome Probiotics formula, and therefore Dr. Simone’s original formula, contains 112.5 billion of the following 8 strains:

  • Lactobacillus paracasei DSM 24733/SD5218
  • Lactobacillus plantarum DSM 24730/SD5209
  • Lactobacillus acidophilus DSM 24735/SD5212
  • Lactobacillus delbrueckii subspecies bulgaricus DSM 24734/SD5210,
  • Bifidobacterium longum DSM 24736/SD5220,
  • Bifidobacterium infantis DSM 24737/SD5219,
  • Bifidobacterium breve DSM 24732/SD5206,
  • Streptococcus thermophilus DSM 24731/SD5207.

Visbiome has shown therapeutic activity in the treatment of diarrhea in children caused by rotavirus (24), as well as in diarrhea associated with antibiotics (25) and in the symptoms of irritable bowel syndrome such as diarrhea (26) and bloating (27) Also noteworthy is its use for remission of ulcerative colitis as demonstrated in a clinical trial conducted on 34 patients with this pathology (28).


  • Dr. Simone’s original formula
  • Backed by numerous clinical studies
  • Registered and patented strains
  • Very potent formula with over 100 billion microorganisms.


  • Quite a bit more expensive compared to other probiotic supplements.

Florastor Probiotic Capsules

? Billon probiotics


1 Strain

Florastor is a probiotic supplement with a single strain, Saccharomyces boulardii CNCM I-745. It is a healthy yeast for the gut and therefore balances the intestinal microbiota.

The Saccharomyces boulardii lyo CNCM I-745 yeast is indicated for various pathologies that produce diarrhea, associated with antibiotics (29), traveler’s diarrhea (30)(31), as well as in the diarrhea produced by Clostridium difficil(32). This is also stated in the World Gastroenterology Organisation Global Guidelines recently updated in February 2023.

Saccharomyces boulardii CNCM I-745 improves digestion by increasing the activity of digestive enzymes and improving digestive problems due to enzyme deficiency. Also, patients with diarrhea benefit from this probiotic due to improved enzyme activity and osmotic effects that make the stools less liquid (33).

It has also shown its efficacy as a treatment for the eradication of Helicobacter Pilory (34).


  • Well-studied probiotic microorganism.


  • Does not specify the amount of millions of cfu so it is not comparable with the rest of probiotic supplements.
  • Contains lactose
  • Only one strain
Florastor Daily Probiotic Supplement (54 Capsules) - Product Not Sold Direct From Manufacturer
Price: $20.28 ($0.38 / Count)
You save: $14.50 (31%)

Nature’s way Pearls Probiotic

1 Billon probiotics


6 Strains

Pearls Probiotic is another product of Nature’s way, an American company with more than 50 years in the natural health products market and with a wide range of products.

Nature’s way Pearls Probiotic is one of the most highly rated and best valued products. Unlike other manufacturers, all the probiotics in this product are registered strains from world-renowned collections.

Each pearl probiotics has 1 billion viable bacteria from a total of 6 probiotic strains:

  • Lactobacillus acidophilus NCFM®
  • Lactobacillus rhamnosus Lr-32®
  • Bifidobacterium lactis Bl-04®
  • Bifidobacterium longum BB536
  • Bifidobacterium breve M-16V
  • Bifidobacterium bifidum bb-02

The exclusive formula of Probiotic Pearls includes a capsule with a special coating that makes it more resistant to the acidic environment of the stomach and bile, thus ensuring that the microorganisms reach the intestine without being previously degraded.

All of them are very common probiotic bacteria among probiotics for gut health and care of the colon, the final part of the large intestine, as well as probiotics that also strengthen the immune system.

Bifidobacterium breve M-16V has been tested in several thousand children with numerous studies, where it has been seen how this microorganism stimulates the increase of bifidobacteria in their intestine.

Bifidobacterium lactis Bl-04 has been widely studied for its therapeutic effect on immunity and allergies, as well as diarrhea associated with antibiotics.

Lactobacillus acidophilus NCFM® is one of the most studied probiotic strains in vitro and with more clinical trials in both humans and animals, being one of the best probiotics today. It has enormous potential to strengthen general health and gastrointestinal health in particular, as well as to boost immune function and reduce the disruption caused by antibiotic intake and irritable bowel symptoms.


  • Registered and patented strains
  • Backed with clinical studies


  • Low potency formula

Nature’s way fortify age 50 probiotic review 

1 Billon probiotics


5 Strains

Nature’s way Pearls Probiotic – For the over 50s it is focused on an older patient where the presence of bifidobacteria declines over the years.

To this end, Nature’s Way offers Pearls Adult 50+ with 1 billion 5 bifidobacteria

  • Bifidobacterium longum BB536
  • Bifidobacterium breve M-16V
  • Bifidobacterium lactis Bl-04®
  • Bifidobacterium infantis M-63
  • Bifidobacterium bifidum Bb-02

Bifidobacteria intake helps return the proper level of bifidobacteria to the intestine, which decreases as we age.

In addition, daily consumption protects against occasional bloatingconstipation, and digestive discomfort. It helps to have more regularityimmunity and health in the colon.

The product is supplied in capsules (pearls) which, like the previous product, also has a triple layer that gives it greater resistance to passage through the gastrointestinal tract.


  • Registered and patented strains
  • Backed with clinical studies
  • Bifidobacteria recovery


  • Low potency formula
Nature's Way Probiotic Pearls Adults 50+, 1 Billion Cultures, 30 Softgels
Price: $13.35 ($0.44 / Count)
You save: $9.14 (41%)

Nature’s way Probiotics

1 Billon probiotics


4 Strains

Another Nature’s Way probiotic. As is customary with this brand, it always identifies not only the species but also the strain which also denotes a product quality that is not always available from competitors.

In this case it is a probiotic with 1 billion bacteria from 4 strains:

  • Lactobacillus plantarum LP-115
  • Lactobacillus acidophilus NCFM®
  • Bifidobacterium lactis BI-04
  • Bifidobacterium longum BB536

The strains used by Nature’s Way in this product are from prestigious companies such as the American Danisco (Dupont) or the Japanese Morinaga Milk.

L. acidophilus NCFM®(a Howaru probiotic) is one of the most studied strains with proven therapeutic ability in treating the symptoms of irritable bowel syndromediarrhea, and constipation (6).

L. plantarum LP-115 has showed an ability to increase the immune response with increased IgG (35).

In another study, in this case in a combination with B. lactis BI-04 and L. acidophilus NCFM® showed to reduce the symptomatology in the case of birch pollen allergy (36).

B. longum BB536 is the strain registered by the Japanese company Morinaga Milk. Although it is not well known among the probiotic products we usually find on the market, it is a clinically documented bacterium with healthy effects for the body by modulating the microbiotaimproving intestinal health and alleviating allergic disorders (37).

A differentiating characteristic of this product is the presence of Lactoferrin, a protein present in breast milk which has, among other properties, the protection of the organism against infections playing a fundamental role in the immune response (38).


  • Registered strains
  • With Lactoferrin to boost the immune system


  • Low potency formula
  • Little variety of probiotics

Nutrition Essentials Probiotic

90 Billon probiotics


11 Strains

Symbiotic Probiotic Supplement from Nutrition Essentials with a 900 billion probiotic of bacillus coagulans 15 B and a prebiotic fiber, FOS (Fructooligosaccharides).

This is one of the best-selling products on the internet, with almost 40,000 positive comments from its consumers.

It is a product that also has a much higher probiotic load than the rest, since it has no less than 900 billion CFU’s of Bacillus coagulans,

Among its properties, improve symptoms of irritable bowel syndrome in both children (39) and adults (40).

It is also effective in treating women who are on antibiotics for bacterial vaginosis (41) as well as patients with acute diarrhea (42) and for treating constipation (43).


  • Powerful formula
  • Study-backed strain


  • Only one probiotic in formula

Healthy Origins Probiotic

30 Billon probiotics


8 Strains

Probiotic from Healthy Origins, an American company with a wide range of health products.

Healthy Origin Probiotic has 30 billion of 8 strains:

  • Lactobacillus. acidophilus La-14
  • Lactobacillus salivarius Ls-33
  • Lactobacillus plantarum Lp-115
  • Lactobacillus rhamnosus Lr-32
  • Lactobacillus casei Lc-11.
  • Bifidobacterium lactis Bl-04
  • Bifidobacterium longum Bl-05
  • Bifidobacterium breve Bb-03

The 8 strains are correctly identified, something that not all manufacturers do, and are from the firm Danisco (Dupont) one of the most internationally recognized probiotic producers.

Among their beneficial properties, the capacity of resistance to stomach acid and bile, the inhibition of growth of pathogenic microorganisms and the modulation of the immune system stand out.

They are also strains with a long history of use, which makes the product safer. It is therefore a product that has all the guarantees of recognized strains and with clinical studies that demonstrate its therapeutic effectiveness.


  • Variety of probiotics in formula
  • Registered and patented strains


  • None identified

Nature’s Bounty Probiotic

20 Billon probiotics


10 Strains

A very complete probiotic supplement with 20 billion of 10 probiotics strains:

  • Lactobacillus plantarum 299v
  • Lactobacillus paracasei DSM 13434
  • Lactobacillus plantarum DSM 15312
  • Lactobacillus bulgaricus Lb-87
  • Lactobacillus brevis Lbr-35
  • Lactobacillus salivarius Ls-33
  • Lactobacillus paracasei Lpc-37
  • Lactobacillus acidophilus La-14
  • Bifidobacterium lactis Bl-04.
  • Lactobacillus casei Lc-11

One of the strains is Lactobacillus plantarum 299v with therapeutic effects for diarrhea (44)(45). This strain is also recommended for the treatment of irritable bowel syndrome (IBS) symptoms, as confirmed by clinical studies (46)(47)(48).

In addition, Nature’s Bounty probiotic is formulated with Lactobacillus paracasei DSM 13434 and Lactobacillus plantarum DSM 15312, with studies demonstrating their therapeutic efficacy in reducing the risk of contracting the common cold (49).

Also, noteworthy is the presence of Lactobacillus bulgaricus Lb-87 with a high capacity to adhere to the intestinal wall, thus inhibiting colonization by pathogenic bacteria. This last characteristic is also present in Lactobacillus salivarius Ls-33 and Lactobacillus casei Lc-11, two other probiotics present in the formula of this Nature’s Bounty probiotic.


  • Patented and proven strains
  • With strains for cold


  • Somewhat expensive price compared to the competition
Probiotics by Nature's Bounty, Ultra Strength Probiotic 10, Immune Health & Digestive Balance, 60 Capsules
Price: $27.13 ($0.45 / Count)
You save: $2.33 (7%)

Dr. Mercola Complete Probiotics

70 Billon probiotics


10 Strains

Dr. Mercola Complete Probiotic containing 70 billion of 10 strains of probiotics: 

  • Lactobacillus acidophilus DDS-1®
  • Bifidobacterium lactis UABla-12
  • Lactobacillus plantarum UALp-05
  • Lactobacillus casei UALc-03
  • Lactobacillus rhamnosus DSM 33560
  • Lactobacillus salivarius UALs-07
  • Lactobacillus brevis UALbr-02
  • Bifidobacterium longum UABl-14
  • Bifidobacterium bifidum UAB-10
  • Streptococcus thermophilus UASt-09

It is one of the probiotics for gut health with the highest concentration of beneficial bacteria for the organism (70 billion) in addition to being a common species in this type of probiotic products.

All the strains are from Chr. Hansen, which guarantees safety and efficacy. Some of them are from the Science Chr. Hansen range, which means more documentation on them and with more supporting clinical data.

Among them, the Lactobacillus acidophilus DDS®-1 strain stands out, as this is a strain from UAS Lab LLC, a company with more than 35 years in the field of probiotics, and which has been studied in clinical trials in both animals and humans.

Among the beneficial effects of this Lactobacillus acidophilus DDS®-1 strain, we have:

  • Reduces the duration of respiratory infections as demonstrated in a study of 225 children (50).
  • Production capacity of acidophilin, an anti-pathogenic substance avoiding being colonized by “bad” bacteria.
  • Reduces symptoms of lactose intolerance, diarrhea, vomiting and cramping (51).
  • Constipation
  • In combination with species of the genus Bifidobacterium, it improves the symptoms of Irritable Bowel Syndrome (52).
  • Prevention of Traveler’s Diarrhea
  • It is also a strain capable of surviving passage through the gastrointestinal tract and modulating intestinal microbiota.


  • Chr Hansen’s reference strains.
  • With Lactobacillus acidophilus DDS®-1, a well-studied strain


  • Expensive compared to competitors
Dr. Mercola Complete Probiotics (70 Billion CFU) Dietary Supplement, 90 Servings (90 Capsules), Digestive Health Support, Non GMO, Soy Free, Gluten Free
Price: $74.97 ($0.83 / Count)
You save: $16.28 (18%)

New Chapter Probiotics

5 Billon probiotics


3 Strains

This probiotic supplement has a total of 10 billion cfu from 3 strains, 5 billion of the strains Lactobacillus plantarum LP01 and Bifidobacterium breve BR03 and another 5 billion strains of Saccharomyces boulardii, a yeast with beneficial effects.

Lactobacillus plantarum LP01 and Bifidobacterium breve BR03 improve the problems of irregularity as well as hard stools, according to a clinical study conducted with 300 patients (53).

They also improve symptoms related to irritable bowel syndrome according to a clinical study conducted in 70 IBS patients (54).

On the other hand, Saccharomyces boulardii is able to bind to pathogenic bacteria such as Escherichia coli or Salmonella, preventing them from colonizing the digestive system. It creates a hostile environment for pathogenic microorganisms through the synthesis of some acids derived from capric and caproic acid.


  • Proprietary strains


  • Formula with only 3 strains
  • Not very potent formula
New Chapter Probiotic All-Flora - 30 ct (1 Month Supply) for Advanced  Immune Support with Prebiotics + Postbiotics for Women and Men + Saccharomyces Boulardii + 100% Vegan +  Non-GMO + Shelf Stable
Price: $25.07 ($0.84 / Count)
You save: $14.05 (33%)

Andrew Lessman Probiotics

10-25 Billon probiotics


4 Strains

It is a mixture of 4 beneficial probiotic, 10 billion or 25 billion of good bacteria for our organism.

  • Bifidobacterium lactis HN019/BL-04
  • Lactobacillus acidophilus La-14
  • Lactobacillus plantarum Lp-115
  • Lactobacillus paracasei Lpc-37

As it has been already commented in other products containing Bifidobacterium lactis HN019, it is a microorganism that improves the gastrointestinal transit in patients with constipation problems (20).

Bifidobacterium lactis Bl-04, on the other hand, stimulates the immune system. In a study of 115 people, prior administration of Bifidobacterium lactis Bl-04 was shown to reduce the incidence of respiratory infection in the group taking the probiotic compared to the group taking the placebo (55).

It also contains the strains Lactobacillus acidophilus La-14, Lactobacillus plantarum Lp-115, Lactobacillus paracasei Lpc-37 that together with Bifidobacterium lactis Bl-04 have been shown to improve digestive health, a lower incidence of diarrheamodulation of the immune system and a lower incidence of bacterial vaginosis in women while providing a rebalancing of the microbiota or intestinal flora (22).

Probiotic from the brand Andrew Lessman, name of the founder of ProCaps, an American company dedicated to probiotic supplements and vitamins (Andrew Lessman vitamins) for more than 30 years.

Product with many beneficial properties for the organism despite the fact that its formula has only 4 probiotic strains.


  • Documented strains
  • Proprietary strains


  • Expensive

TruBiotics Daily Probiotic